There are no specific drawbacks within the use of Zyxelle®. Usually Centella Asiatica is a safe and well-tolerated supplement. However, during pregnancy and breastfeeding, women are usually discouraged from taking it. In literature there are, in fact, studies revealing its potential uterine muscle relaxant effect. Moreover, it should be avoided during breastfeeding, as small doses might result toxic for the baby. For further details or in case of doubt, consult your doctor or pharmacist.